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New Objective - Leaders in Nanospray Innovation
Leading high-sensitivity LC-MS research through innovative life science sample prep and delivery tools.
PicoTip Introduction Kits
Nanospray / Electrospray Tip Kits available from Scientific Instrument Services, Inc.Glass PicoTips
Nanospray / Electrospray tips available from Scientific Instrument Services, Inc.Fused Silica PicoTips
Nanospray / Electrospray tips available from Scientific Instrument Services, Inc.TaperTip
Nanospray / Electrospray tips with taper only on the external surface. Available from Scientific Instrument Services, Inc.Metal TaperTip
Nanospray / Electrospray tips with taper only on the external surface. Available from Scientific Instrument Services, Inc.ESI Emitters for AB Sciex NanoSpray® III Ion Source
Silica Tips used.PicoFuze
PicoFuze columns combine proven high-performance of PicoFrit columns with the ease-of-use format of PicoChip columns

Introduction
New Objective - Leaders in Nanospray Innovation
Leading high-sensitivity LC-MS research through innovative life science sample prep and delivery tools.
Founded in 1997 on PicoTip™ technology, a revolutionary line of emitters for LC-MS, New Objective has remained on the cutting edge of nanobore chromatography and nanospray-based mass spectrometry through close communication with our customers, continuous innovation, and dedication to quality.Fused-silica PicoTip® emitters for online electrospray are available in the SilicaTip™ and the TaperTip™, which differ in size and operational flow rates. TaperTips are very robust emitters used in microspray applications.Your emitter-mounting hardware must accommodate 150 or 360 µm out-side diameter (OD) fused-silica tubing.
Bring Electrospray into Focus with a New Objective PicoTip!
Break the 1 µl/min barrier. Upgrade your conventional ESI emitter to a New Objective glass or fused silica PicoTip™. Scanning Electronic Microscopy reveals the PicoTip secret: A microfabricated structure perfect for low-flow rate ESI-MS. Unlike some products from other suppliers, there is no need to break open or grind PicoTips™ prior to use.
Coating Options
In order to perform electrospray, high voltage must be supplied to the mobile phase. The electrical contact can be made in either of two methods— indirectly through a conductive coating on the emitter, or directly through a junction. Each of these methods requires different styles of emitters.Once you have determined your contact method, select the corresponding coating. Distal coatings are most durable.Junction Contact with Distal-Coating (D)
The electrical contact is made to the outside of the emitter, which has a conductive coating on the distal end. The voltage contacts the mobile phase through the gap between the emitter and the transfer line. PicoTips® with a distal coating have -D- in their stock numbers. Use primarily with PEEK™ fittings.
Tip Contact Using the Standard Coating (CE)
The electrical contact is made to the outside of the emitter. The emitter has a conductive coating on the tip where the voltage contacts the mobile phase. PicoTips with a standard coating have - CE- in their stock numbers.Use primarily with PEEK fittings.
Junction Contact for Uncoated Tips (N)
The electrical contact is made to the fitting holding the emitter. Voltage con-tact is made directly to the mobile phase. PicoTips that are uncoated have-N- in their stock numbers. Use primarily with metal fittings.
Application
Ask us about custom orders!
Wide-bore and narrow-bore Picotips™ can be nested to create versatile, ultra-low volume ESI emitters. Here, a 30 µm tip fabricated from 360 µm OD tubing has been inserted into a 15 µm tip made from 450 µm ID (670 OD) fused silica tubing.
Patented Multi-layer Conductive Coatings
New Objective uses a patented (U.S. Patent 5,788,166), multi-layer coating process. Our pure gold layer is overcoated with an inert, electrochemically stable dieletric layer, locking the gold into place. The resulting coating has excellent resistance to ESI solvent exposure and exceptional electrochemical stability. To try and improve coating performance, other manufacturers increase the mechanical durability of the gold layer by introducing alloy or inter-layer metals. During handling the coating may appear to be more durable, but it may not yield improved ESI performance. These alloy and inter-layer metals can actually reduce the coating's electrochemical stability resulting in coating degradation at the tip.
Stability With Stop/Start Performance
The figure on the left shows the stability of signal at three time scales. The modulation in current is due to turning the spray voltage on and off. Note how the ion current returns to its former level. This tip was sprayed without failure for over 3 hours and was "retired" still functional. The total ion current is (through 3 RF-only quadrupoles) from a 360, 50 (ID/OD) needle with a 5 µm ID tip, operating at 60 nL/min spraying 20 µM Ubiquitin in 2% HoAC.
Select the right tip for your mass spectrometer For optimal results - and without the need of additional equipment - some mass spectrometers require a specific size emitter. The most common systems and their respective emitters are:
Choose a Tip with a Tubing O.D. of 1.2 mm for:
ABI Mariner™/QSTAR®
Bruker Nanospray™
Protana NanoES Source
Thermo Finnigam Nanospray Ion Source
Choose a Top with a Tubing O.D. of 1 mm for:
Micromass® ZSpray™ NanoFlow™