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VOL. XXIII, NO. 1 Scientific Instrument Services, Inc. June 2001

This is the first edition of the SIS Mass Spec Source Newsletter via our Web Site. We anticipate that we will send this communication out once every 2 months. In it we will keep you informed of news at SIS, trade shows that we will be attending, new products being introduced and promotions on products.

To receive your copy of this newsletter or to get on our mail list, please fill out our survey form.

You are being sent this newsletter, because you requested it on line from our SISWEB home page on the internet or because you filled out one of our survey forms. If you do not wish to continue to receive this newsletter, please respond to us via e-mail and request that we delete your name from our e-mail newsletter list.


SIS Continues to Expand its Facilities to Serve the Scientific Market

SIS is continuing to expand our facilities and staff to better serve the needs of the scientific community. In the past 6 months we have added a total of 5 new technical people to our shop facilities. This is a 25% increase in staff which brings our total staff size to 25 people.

SIS has made major efforts in the past year to expand our machine shop. We have added a new computer controlled 4 axis vertical machining center (CNC Mill) and a multi-axis Mori Seiki turning center (CNC Lathe) to the machine shop. We now have a staff of 3 full time machinists in the machine shop to operate this equipment. This new equipment permits us to machine parts and components for end users, OEM's as well as our own parts for the thermal desorption systems and probes we develop and market.

The following brochures describing our company, our shop facilities and the services we offer are available in the pdf files listed here:

Our manufacturing begins with 3-dimensional Computer Aided Design (CAD) of parts and assemblies using CadKey software on a PC. These drawings are then downloaded to another PC with Computer Aided Machining software (CAM). The CAM software converts the CAD drawing into the CAM format which can then generate the tools and machining tool paths for the machining of the part on the CNC equipment.
Next the tool paths and tool selection generated by the CAM software is downloaded to the CNC equipment for machining of the components. The correct tooling is automatically loaded by the automated tool loaders into the CNC machine. The feed and cutting speeds for the selected tools are determined by the software depending on the materials being machined and the part is machined to the required specifications with tolerances better than 0.002" Complex parts can be machined due to the 4 axis capabilities of the equipment.
After the parts are manufactured they are cleaned in our new Crest Closed Loop Ultrasonic Cleaning system. This system uses no organic solvents, only water, for the cleaning process. The water is continually recycled through ion exchange resins and carbon filters to maintain its high purity. The parts to be cleaned are immersed in the high purity water at elevated temperature and ultrasonics are used to super clean the parts until they are totally free of any contamination.
The result is a high precision manufactured part at reasonable cost.

A number of brochures describing out machine and repair shop facilities and capabilities can be downloaded from our web site.


SIS Obtaining ISO Certification

SIS is in the process of obtaining ISO Certification. ISO is an international program to provide for quality and improved customer service in an organization. It is comparable to GLP in a laboratory. Companies that are certified must document all their procedures and processes, provide for inspection and high quality control for their products and strive for continued quality improvement and customer satisfaction.

We made a decision to pursue ISO Certification about a year ago in order to improve our quality control procedures, to improve customer service, to better document what we do and the way we do it, and to position the company to better serve the needs of the scientific community. We started the ISO Certification process about 3 months ago and are well underway in the process. We hope to achieve final certification in December of this year. We anticipate that you will see the impact of the changes that will occur as a result of this program.


SIS at the ASMS meeting in Chicago - Annual SIS Ice Cream Hospitality Suite

SIS will be attending the ASMS meeting on May 27 to May 31, 2001 at the Hyatt Regency Hotel in Chicago. Stop by the SIS Booth during the meeting,

The Tradition Continues at ASMS

Once again we will be sponsoring our Ice Cream Sundae Hospitality Suite at the Atlanta room in the Hyatt Regency Hotel. We will be serving ice cream sundaes from approximately 7:30 p.m. until 9:30 pm, on Monday, Tuesday and Wednesday evenings. Both SIS and DeTech will be present in the SIS Hospitality Suite to answer your questions, discuss your current and future projects and to solicit your input as to how we can better serve your needs. So come on by and pay us a visit.


SIS AutoProbe™ introduced at PittCon 2001

SIS introduced the AutoProbe™ - an automated direct probe for the Thermo Finnigan TRACE™ mass spectrometer at this year's PittCon meeting in New Orleans.

The AutoProbe System is an Automated Direct Exposure Probe (DEP) for the Finnigan TRACE Mass Spectrometer System with a dual EI/CI source. The AutoProbe System injects samples directly into the MS source for mass spec sample analysis with no chromatographic separation. This permits samples to be analyzed in 3 minutes or less. The AutoProbe operates in the Thermo Finnigan Xcalibur™ MS Software environment and is fully integrated with the Xcalibur software, including system setup, methods setup, system operation and data storage.

Applications of the direct probe technique include the screening of drug and pharmaceutical samples, quality control sample analysis, spot analysis of chemical reaction mixtures to monitor rates of synthesis, and the analysis of compounds which cannot be chromatographed. The AutoProbe System is used where high volumes of samples need to be analyzed quickly or it can be used in an "Open Access" environment where it can be operated by multiple users with minimal MS expertise.

Additional Details on the AutoProbe are available on our WEB site in the following files.

AutoProbe General Description
AutoProbe Console Description
AutoProbe Software Description
AutoProbe Specifications and Requirements

or download the 6 page color flyer on this product (506 K)

AutoProbe Flyer (PDF 506K)

We currently have four application notes on the use and application on the AutoProbe.

87. Design and Development of an Automated Direct Probe for a Mass Spectrometer
89. Quantitation of Organics via a Mass Spectrometer Automated Direct Probe
90.  An Automated MS Direct Probe for use in an Open Access Environment
91.  AutoProbe DEP Probe Tip Temperatures

Vacuum Pump Exhaust Filter System from SIS

SIS has recently introduced vacuum pump filter kits for the rough pumps on your MS systems. These systems are recommended for areas where it is not possible or practical to exhaust the MS vacuum pumps outside the building. The filter system consists of two layered filters. The first filter is an oil mist eliminator, which captures the heavy hydrocarbons from the vacuum pump exhaust and returns these oils back into the pump. The second stage of filtering, consists of a disposable charcoal trap, which traps the more volatile organic compounds which are exhausted from the vacuum pump. Four different Exhaust Filter Kits are now available for a large selection of vacuum pumps.

We have complete Exhaust Filter Kits for specific models of vacuum pumps. Each kit includes a Koby Charcoal Trap, an Oil Mist Eliminator and all the fittings, centering rings, and clamps needed to complete the assembly of the filter system to the vacuum pumps. For additional details on the kit contents, descriptions and pictures, click onto the Kit # to link to the appropriate WEB page.

Two Stage Filter Kits for most Vacuum Pumps are available from SIS.

We have three application notes on our web site with scientific studies demonstrating the effectiveness of these vacuum pump exhaust filters.

A four page flyer on vacuum pump filters can also be downloaded from our web site (478 K).

Vacuum Pump Exhaust Filter flyer


Sale on Excess Inventory of J&W Capillary Columns

Agilent is now shipping J&W columns in Agilent boxes. As a result we are trying to clear our shelves of the old J&W columns. To accomplish this we are offering a discount of 50% off the list price of these columns to our customers. There is no additional quantity discount on these columns. They will be sold on a first-come / first-served basis. When the stock listed in the attached spreadsheet is gone, the prices will revert back to the new prices.

Available from Scientific Instrument Services, Inc.- US Pricing ONLY - Limited Quantities ONLY

Special Pricing on J&W Capillary Columns in Stock at SIS
Part # Phase Description Length (m) I.D. (mm) Film (u) Quantity List Price Special Price Catalog Page
1122532 CYCLODEX-B 30 0.25 0.25 1 $446.00 $223.00 D26
1125432 SE54 30 0.25 0.25 1 $464.00 $232.00 D29
1132532 CYCLODEX B 30 0.32 0.25 1 $478.00 $239.00 D26
1220712 DB-1701 15 0.25 0.25 3 $251.00 $125.50 D29
1221063 DB-1 60 0.25 1.00 SOLD $727.00 SOLD D22
1221131 DB-1HT 30 0.25 0.10 SOLD $464.00 SOLD D23
1221212 DB-XLB 15 0.25 0.25 1 $288.00 $144.00 D29
1221233 DB-XLB 30 0.25 1.00 3 $473.00 $236.50 D29
1221334 DB-624 30 0.25 1.40 1 $443.00 $221.50 D25
1221712 DB-17 15 0.25 0.25 2 $247.00 $123.50 D23
1222462 DB-DIOXIN 60 0.25 0.25 1 $758.00 $379.00 D29
1225631 DB-5.625 30 0.25 0.25 SOLD $440.00 SOLD D25
1225632 DB5.625 30 0.25 0.50 1 $440.00 $220.00 D25
1225711 DB-5HT 15 0.25 0.10 SOLD $283.00 SOLD D23
1227031 DBWAX 30 0.25 0.15 1 $415.00 $207.50 D25
1227032 DB-WAX 30 0.25 0.25 SOLD $415.00 SOLD D25
1231062 DB-1 60 0.32 0.25 1 $792.00 $396.00  
1231063 DB-1 60 0.32 1.00 1 $792.00 $396.00 D22
1231065 DB-1 60 0.32 5.00 1 $792.00 $396.00 D22
1231131 DB-1HT 30 0.32 0.10 2 $494.00 $247.00 D23
1231534 DB-VRX 30 0.32 1.80 1 $511.00 $255.50 D26
1232462 DB-DIOXIN 60 0.32 0.25 1 $809.00 $404.50  
1233812 DB-35MS 15 0.32 0.25 1 $312.00 $156.00 D24
1235031 DB-5 30 0.32 0.10 1 $448.00 $224.00  
1235063 DB-5 60 0.32 1.00 1 $792.00 $396.00 D20
1235513 DB-5MS 15 0.32 1.00 1 $312.00 $156.00 D21
1235536 DB-5MS 30 0.32 0.50 1 $510.00 $255.00 D21
1235563 DB-5MS 60 0.32 1.00 1 $876.00 $438.00 D21
1237033 DB-WAX 30 0.32 0.50 2 $448.00 $224.00 D25
1237056 DB-WAX 50 0.32 1.00 1 $610.00 $305.00  
1250212 DB-210 15 0.53 1.00 1 $279.00 $139.50 D31
1251017 DB-1 15 0.53 0.50 1 $274.00 $137.00 D22
1251037 DB-1 30 0.53 0.50 2 $497.00 $248.50 D22
1251374 DB-624 75 0.53 3.00 2 $1,011.00 $505.50 D25
1255012 DB-5 15 0.53 1.50 1 $274.00 $137.00 D20
1255532 DB-5MS 30 0.53 1.50 1 $561.00 $280.50  
1261013 DB110M 10 0.05 0.20 1 $453.00 $226.50  
1285552 DB-5MS 50 0.2 0.33 1 $659.00 $329.50 D21

Available from Scientific Instrument Services, Inc.- US Pricing ONLY


Mass Spec Desk Reference by O. David Sparkman

The Mass Spec Survival Guide - Whether you are a newcomer, teacher, manager, or experienced practitioner engaged in mass spectrometry, you will find this handy desk reference an invaluable tool for improving your results


SIMION 3D version 7.0 Ion and Electron Optics Program

SIMION 3D version 7.0 is a PC based ion optics simulation program designed for instrument design of mass spectrometers and other ion optic instruments. At SIS we use this program to design new mass Spectrometer filaments and to study mass spec source design. Manufacturers of electron multipliers use this software to design their detectors and instrument designers use it to design new instruments and to maximize the sensitivity of the instruments. Use this powerful software to study ion source and detector optics in time-of-flight, quadrupole, ion trap and magnetic sector mass spectrometers in order to discover improvements that can be made to your instruments as well as to develop new instrument designs.

SIMION 3D Flyer (PDF)

This is a new version of SIMION. There is no upgrade price.


NIST / EPA / NIH Mass Spectral Library

The latest version on NIST 98, Version 2.0 (January 2001) is now available. Included with this release is the NIST/EPA/NIH Mass Spectral Library (129,136 EI Mass Spectra of 107,886 Compounds with 107,829 chemical Structures), Search Program Version 2.0, and AMDIS Mass Spec Interpreter Version 2.1.

There are many new features in the program, some of the most important are:

  • Structure searching - the program will now find all data based on its structural similarity. The searching can be done with either data from the NIST MS database, the user database or from a structure drawn in most chemical drawing packages.
  • Drag and Drop - Data can be dragged and dropped between window.
  • User Library Structures - Present since version 1.6, but possibly new to some of you.
  • Compare Views - There are a number of new ways that you can visually compare two spectra.
  • Direct interaction with a number of chemical drawing packages - the clipboard can be used with some of them, most can be used by use of intermediate files.

The most important changes are in the overall user interface. The user interface should be easier to use and more conformant with normal Windows conventions.

NIST Color Flyer (PDF)

System requirements
The program is a true 32 bit program and thus requires Windows NT, 95,98 or 2000. This is a beta version of the installation, the program and the help file.

* For an Upgrade you must be the owner of a registered version of the program.


5900 MAGNUM ELECTRON MULTIPLIER™

For HP 5770A, 5970, 5970B, 5971A, 5972A, GCD, 5973, 5989A, 5989B, M.S. Engine, and 5995 Mass Spectrometers

  • High Performance
  • Linear Over Wide Range of Output Current
  • Low Noise
Direct Plug-in Replacement for OEM Multiplier
 

The BURLE Magnum Electron MultiplierTM has exceptional performance to achieve optimum mass resolution, dynamic range, and detection sensitivity for Mass Spectrometry measurements.

The sensitivity of your instrument is often limited by the detector. Benefiting from our exclusive SPIRALTRON technology, BURLE's Magnum Mass Spectrometer detector provides the highest dynamic range in the industry, as well as delivering increased gain stability and extremely low noise.  The SPIRALTRON technology incorporates six individual spiral multiplier channels, fed by a single integral ion collection aperture. The high degree of channel curvature ensures that ion feedback noise is virtually eliminated.

BURLE's replaceable Magnum cartridge can be installed quickly with a minimum of instrument down time. Installation can be performed by any instrument operator eliminating the need for an expensive factory service call. Each cartridge is specifically designed to be an exact replacement for the original detector cartridge. You don't have to buy an ion optics frame to replace the detector cartridge

  • 5900 MAGNUM™ - HP (Agilent) Original Plug in Replacement
  • 5901 MAGNUM™ - For Pulse Counting Applications (not normally used)
  • 5902 MAGNUM™ - HP (Agilent) systems that have been retrofitted with the K&M Replacement (Note - This multiplier is larger in diameter and will not fit into the original HP mount)

For additional information on multipliers, see our Multiplier Page.