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SIS Mass Spec Source Newsletter, June 2000

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VOL. XXII, NO.2 June 2000

Features in the June 2000 MS Source Newsletter

This is a compilation of the materials in the SIS June 2000 newsletter which was printed and mailed out in early June 2000.  To receive your copy of this newsletter or to get on our mail list, please update your name on our mail list and request this newsletter by filling out our survey form.

Vacuum Pump Exhaust Filter Article

The first of three articles reporting on the effectiveness of filters designed for use on the exhaust of vacuum pumps.

Replacing a DeTech  Electron Multiplier in the Agilent 5973 MSD

Replacing an electron multiplier can be successfully accomplished in just 15 minutes after the instrument is cooled down to the touch. All that is required are a pair of clean room gloves and the DeTech Model 2300 Electron Multiplier.

 SIS Monthly E-mail Newsletter

Beginning in July, SIS will be distributing a monthly e-mail newsletter on SIS products, services, promotions, news and other mass spectrometer related information. To receive this free newsletter fill in the attached form with your e-mail address and return it to SIS by mail or drop it off at the ASMS meeting.

Mass Spec Desk Reference by O.David Sparkman

The Mass Spec Survival Guide  - Whether you are a newcomer, teacher, manager, or experienced practitioner engaged in mass spectrometry, you will find this handy desk reference an invaluable tool for improving your results.

ASMS 2000 Mass Spec User Survey

Please fill out and return this form to update your name on our mail lists to receive one or more of the following:

  • SIS 2000-2001 GC MS Catalog in Printed form
  • SIS 2000-2001 GC MS Catalog on CD
  • Mass Spec Source Newsletter in Printed Form
  • New - SIS E-Mail Newsletter

The Tradition Continues at ASMS

Once again SIS will be attending the annual ASMS meeting in Long Beach California on June 12 - 15. SIS will be providing our traditional ice cream treats in our ASMS suite. The SIS hospitality suite hours will be Monday through Wednesday from 7:30 - 10:30 pm. Stop by and receive our free 10-in one screwdriver after filling out the attached survey form.  We have invited three other companies to share our suite. These include DeTech, the fastest growing manufacturer of mass spectrometer detectors, Prolab Resources, a service company and manufacturer of replacement data systems, and Mass Sensors, a manufacturer of small mass spectrometers for process analytical and educational uses. In addition SIS will be sponsoring lunchtime presentations at our hospitality suite. (See next page.)

1. Controlling Laboratory Air Contamination from Rotary Vacuum Pumps by Using a Two-Stage Vacuum Pump Exhaust System. by John Manura - Poster # 1270

2. Analysis of Silicone Contaminants on Electronic Components by Thermal Desorption GC-MS. by Eric Butrym - Poster # 1425


SIS Topical Seminars at ASMS

SIS is sponsoring three introductory seminars at this year's ASMS conference. Each presentation is designed as an introduction to the selected topic. These walk-in sessions will be held from 12:15 - 1:00 on each day in our hospitality suite, Hyatt Seaview C (first floor).

Monday Lunch

Applications of Thermal Desorption - Volatile and Semi-Volatile Analysis in Air by Stuart Batterman, University of Michigan

Air sampling using sorbents, thermal desorption, and gas chromatography is a versatile method for identifying and quantifying trace levels of volatile organic compounds (VOCs). Points to be discussed include the appropriate choices of sorbents and method parameters in order to accommodate a wide range of compounds and high humidity. The advantages of an automated short-path system for minimizing artifacts, losses, and carry-over effects are illustrated. As examples, results will be presented that demonstrate the performance of a thermal desorption method for 77 VOCs using laboratory and field tests and a dual sorbent system (Tenax® GR, Carbosieve SIII). Laboratory tests showed that the method requirements for ambient air sampling were easily achieved for most compounds, e.g., using the average and standard deviation across target compounds, blank emissions were ≤0.3 ng/sorbent tube for all target compounds except benzene, toluene and phenol; the method detection limit was 0.05 ±0.08 ppb, reproducibility was 12 ±6%, linearity as the relative standard deviation of relative response factors was 16 ±9%, desorption efficiency was 99 ±28%, samples stored for 1 to 6 weeks had recoveries of 86 ±9%, and high humidity samples had recoveries of 102 ±11%. Due to sorbent, column and MSD characteristics, performance was somewhat poorer for phenol groups, ketones, and nitrogen containing compounds. The laboratory results were confirmed in an analysis of replicate samples collected in two field studies that sampled ambient air along roadways and indoor air in a large office building. Replicates collected under field conditions demonstrated good agreement except at very low concentrations or for large (> 4 l volume) samples of high humidity air. Overall, the method provides excellent performance and satisfactory throughput for many applications.

Tuesday Lunch

How AMDIS Could Have Saved My Sister's Marriage by O. David Sparkman

AMDIS attempts to reconstruct original mass spectra for individual components in arbitrarily complex GC/MS and LC/MS reconstructed total ion current (RTIC) chromatograms and, if a target library is provided, AMDIS can directly identify target compounds. AMDIS is especially useful when an RTIC chromatographic peak represents multiple components. Regardless of each component's concentration, pure mass spectra are deconvoluted for analysis.

AMDIS has been designed to reconstruct "pure component" spectra from complex RTIC chromatograms even when components are present at trace levels. For this purpose, observed chromatographic behavior is used along with a range of noise-reduction methods. AMDIS is distributed with specialized libraries (environmental, flavor and fragrance, and drugs and toxins), that were derived from the NIST98 Library. AMDIS has a range of other features, including the ability to search the entire NIST98 Library with any of the spectra extracted from the original data file. It can also employ retention index windows when identifying target compounds and can make use of internal and external standards maintained in separate libraries. A history list of selected performance standards is also maintained.

Wednesday Lunch

LC/MS Fundamentals and Applications by Mike Lee, Milestone Development Services

Abstract: The combination of high-performance liquid chromatography and mass spectrometry (LC/MS) has had a significant impact on industrial applications over the past decade. Continual improvements in LC/MS interface technologies combined with powerful features for structure analysis, qualitative and quantitative, have resulted in a widened scope of application. An iterative cycle of "what is it?" and "how much is there?" continues to fuel the tremendous growth of LC/MS. This talk will review the fundamentals of LC/MS and provide perspective on strategies for method development. Current applications of LC/MS technologies and emerging industry trends will also be discussed .


"The Mass Spec Source" Editorial Board & Newsletter Staff

John J. Manura
Christopher W. Baker
Dr. Steve Colby
Eric Butrym
J. Philip Tielmann,
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