Nanoliter Dispensing Devices

Nanoliter dispensing devices can be used to place media on the MALDI plates for MALDI/TOF instruments, but the most exciting ability of this device is to collimate droplets directly into the ion source like electrospray (ESI), the unique concept being that nearly 100% of the droplets go directly into the source versus <1% from ESI, giving a huge increase in sensitivity. We believe this could be the next big advance in LC/MS sources. One Nanoliter Cool Wave device can be used to make excellent MALDI crystals or shoot 100% of your sample into your ESI source!

This one device provides major sensitivity and reproducibility increases for ESI & MALDI. Spraying dangerous, radiochemicals, neurotoxins, poisons, proteins all over your instrument? Now you can shoot drops like this (• • • • • • • • • •).

It uses 100% ESI efficient, "all in" induction based fluidics (IBF) technology. [A. Grange, A. Sauter, ASMS 2010, 2011]

Form excellent MALDI crystals, 3D Print!

Various configurations of an IBF dispenser are shown above.

NEW! Very rapid fire droplet ME for FIA, LC/ESI/MS, LC/MALDI analysis, and R&D. Millisecond MS sample analysis is the fastest in the world.

Directly analyze: liquid products, cells, blood, bio-flui agents, radiochem., viscous, and any liquid.

Videos

Induction Based Fluidics (IBF)

Nanoliter devices use Induction Based Fluidics (IBF) to dispense, treat, purify or chromatograph liquids. In IBF, liquids are charged which launches them to targets of all types (e.g., MALDI plates, humans, microscope slides, TLC or microtiter plates, mass spectrometers, optical cells, almost anything). The liquid drops fly, field directed to locales where they can be measured on arrival, like ions in mass spectrometers. IBF is a new, simple way to transport & treat liquids for many purposes.

Through the presentation of the physics of IBF in many peer reviewed publications, it has been shown, unlike devices that employ piezoelectric, sound, or other technologies that are applied to transport liquids at low volumes, that IBF technology can 1) kinetically project drops to targets of all types, 2) dynamically direct the liquids in flight to targets (a required, trait for small volumes of liquids) and details depending 3) count them on arrival. This simple technology has been called "elegant" by the former Director of R&D at Sciex. Some of America's leading mass spectrometrists have called the technology and our ability to shoot 100% of cell contents, cell liquids and other samples, like water, into MS's, "exciting."

The nanoliter regime offers a number of obvious benefits over larger volume regimes in the lab and elsewhere. These include significant savings of expensive reagents, major reduction in human exposure to toxic chemicals, allergens, agents, viruses, etc. The nanoliter regime also reduces waste disposal costs. Because IBF has a massive dynamic range (µL to fL), it has a substantial application space. It is a useful laboratory tool that has broad applications elsewhere. For example, IBF can be used for simple sample dilution; the analysis of proteins, peptides and synthetic polymers by MALDI; other sample preparation in chemical analysis; drug delivery; drug discovery; radiochemistry; homeland security/defense applications; forensics; the sampling of or drug delivery to human beings; in medical diagnostics; and in the manufacture of unique chemical and other entities, e.g., polymers and electrets. Finally, IBF also allows non-touch dispensing in the microliter regime as well for more classical assays, and it also has interesting consumer applications, e.g., gluing.

Ordering

Contact us for for further details and to discuss your requirements. Each source is custom built.

Contacting our Customer Service Department--comments, questions, or anything can't find?

Call, e-mail, FAX, or type your comments below:

Contact details (optional, but required for us to reply or quote):

Name:		Organization/Country:
Email:		Phone/fax:

Regular business hours - 8:00 AM to 5:30 PM EST, M-F. E-mail replies normally expected within one business day.

PHONE: (908)788-5550;   FAX: (908)806-6631;   E-MAIL:

WEB: www.sisweb.com
ADDRESS: Scientific Instrument Services, 1027 Old York Rd., Ringoes, NJ 08551-1054.