ShearMax™ Homogenizers| Overview | FAQ | Purchase |
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Want to know more about homogenization methods in general? Click here for an overview.
Force Action Shearing Technology is really a synergy between two key components of the ShearMax™. The first is the high-speed motor, which generates extremely high RPMs. The second is the precision manufactured homogenization probe. These two components are what really enable the ShearMax™ to produce very large amounts of shear and also produce cavitation.
Shear, or shear stress, is a measure of the tangential force applied to an object in relation to the cross-sectional area of that object. Put simply, it's the result of applying a force parallel to an object as opposed to head-on. This shear stress causes shear strain, which is the relative movement of surfaces in an object. If one surface moves enough with respect to the other, the material will rip. In terms of laboratory homogenization, shear stress and shear strain are what rip apart tissue and tear open cells and organelles.
Cavitation is the rapid formation and destruction of transient bubbles of vapor inside a liquid caused by sudden and localized drops in pressure within the liquid. When these transient bubbles are destroyed, they release very small shockwaves. These shockwaves serve to destroy membranes. This is actually very important for laboratory homogenization as smaller particles may not experience as much shear.
The ShearMax can homogenize a wide range of samples, but we designed it with biological samples in mind. Just about any cell types can be homogenized in a ShearMax. It can also homogenize relatively tough tissue. As a general guideline, tissue as tough as muscle can be homogenized using a ShearMax™. Please note that when using tissue or other non-aqueous materials, you will need to add a buffer. Please refer to the operator's manual for further details.
The ShearMax handheld homogenizers are capable of homogenizing many types of samples over a very wide volume range. Depending on the size and physical properties of your sample, the time it takes to homogenize them will vary - from a few seconds for small samples, to a minute or two for large samples.
The homogenization probes can be cleaned by washing with a detergent, alcohol, or other cleaning solution. Alternatively, they can be autoclaved (wet or dry). Flaming is not recommended since the inside of the probe may not get properly disinfected or cleaned in this manner.
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