by Hans H. Maurer, Dirk K. Wissen, Armin A. Weber, June 2018
A major goal in clinical and forensic as well as in doping laboratories is a broad screening procedure for detection of toxic compounds or drugs of abuse. In addition to GC-MS and LC-MSn screening techniques, LC-high-resolutiontandem mass spectrometry (LC-HR-MS/MS) provides various advantages for screening approaches such as higher versatility, sensitivity and specificity. The Maurer/Meyer/Helfer/Weber LC-HR-MS/MS Library of Drugs, Poisons, and Their Metabolites is the basis for metabolite-based screening procedures described for various drug classes.
Detection of metabolites increases selectivity, allows confirmation of the body passage, and finally, minimizes the risk of false negative LC-MS results possibly caused by ion suppression of the target analyte. The LC-HR-MS/MS library features over 2,000 parent drugs or poisons, and over 3,000 of their metabolites or artifacts in over 95 compound classification groups.
Compound Coverage (over 95 compound classifications)
- Drugs of Abuse, NPS
- ... and more
Compatible with: NIST MS Search and MMHW LC-HR-MS/MS Library
About the Authors
After having published several editions of the unique Maurer/Pfleger/Weber: Mass Spectral Library of Drugs, Poisons, Pesticides, Pollutants and their Metabolites, Wiley-VCH, Weinheim (Germany), Hans H. Maurer started in 2008 together with his coworkers Dirk K. Wissenbach and Armin A. Weber to develop this first metabolite-based LC-MSn library of Drugs, Poisons, and their Metabolites. Under guidance of Hans Maurer, Dirk K. Wissenbach developed the corresponding urine drug screening during his PhD studies and the mass spectra collected for this screening have been the basis of this new library. After completion of his PhD, he moved to the Helmholtz Centre for Environmental Research in Leipzig, Germany, where he is involved in MS-based research on the environmental impact on the human metabolome. Armin A. Weber, already coauthor of the GC-MS library, is involved in various research projects and particularly responsible for all technical and software developments also for this data collection.
|9783527343386||MMHW LC-HR-MS/MS Library of Drugs, Poisons, and their Metabolites||$3000.00|
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- LC-MSn Library of Drugs, Poisons and Their Metabolites, 2014 The world's most comprehensive reference for clinical and forensic toxicologists is keeping pace with recent developments in clinical and forensic toxicology.